2014年9月28日 讯 /生物谷bioon/ --研究发现,卵巢癌是女性妇科癌症中最致命的疾病,有研究表明妇女在她们生命期限中约有50%的几率会患有此病,渥太华和台湾研究人员针对此项研究发表了相关文章在《美国国家科学院院刊(pnas)》上,文章关于为什么卵巢癌通常对化学疗法具有抗性这一观点提供了新的见解,以及对改善其诊断和治疗方法提供了一种可能性
mohammad r. abedinia,b,c,1, pei-wen wangd,1, yu-fang huange,1, mingju caoa,b, cheng-yang choue,2, dar-bin shiehd,f,2, and benjamin k. tsanga,b刘晓庆如何保养卵巢,2
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根据《加拿大卵巢癌》杂志相关数据估计,2014年大约有2700名加拿大妇女被诊断为卵巢癌,约有1750名妇女因此而丧生该病通常在其晚期时才能被诊断出,而此时卵巢癌已经对化疗产生了抗性
chemoresistance is a major hurdle in cancer treatment. down-regulation of apoptosis pathways is one of the key determinants for chemoresistance. here, we report higher gelsolin (gsn) lev卵巢保养吃什么els in chemoresistant gynecological cancer cells compared with their sensitive counterparts. cis-diammine dichloroplatinium (ii) (cddp)-induced gsn down-regulation is associated with its cleavage and apoptosis. although the c-terminal gsn fragment (c-gsn) sensitized chemoresistant cells to cddp, intact gs卵巢癌n and its n-terminal fragment (n-gsn) attenuated this response. gsn silencing also facilitated cddp-induced apoptosis in chemoresistant cells. in contrast, intact gsn (i-gsn) was prosurvival in the presence of cddp through a flice-like inhibitory protein (flip)-itch interaction. this interaction was coloc刘晓庆如何保养卵巢alized in the perinuclear region that could be dissociated by cddp in sensitive cells, thereby inducing flip ubiquitination and degradation, followed by apoptosis. in resistant cells, gsn was highly expressed and cddp failed to abolish the i-gsn-flip-itch interaction, resulting in the dysregulation 卵巢保养吃什么of the downstream responses. in addition, we investigated the association between gsn expression in ovarian serous adenocarcinoma and progression free survival and overall survival, as well as clinical prognosis. gsn overexpression was significantly associated with more aggressive behavior and more 刘晓庆卵巢内裤cancer deaths and supported our hypothesis that high gsn expression confers chemoresistance in cancer cells by altering the gsn-flip-itch interaction. these findings are in agreement with the notion that gsn plays an important role in the regulation of gynecological cell fate as reflected in dysregu卵巢襄肿吃什么好lation in chemosensitivity.
doi:10.1073/pnas.
另外,使卵巢癌细胞对化学疗法有抗性的一个相同的蛋白能够克服这种治疗上的障碍通过切断钙结合微丝蛋白使之分成为特殊的片段,并将这个片段嵌入到有化疗抗性的癌细胞中,该研究团队发现这些细胞对具有肿瘤杀死作用的化疗药物顺铂变得非常敏感
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研究者展示了钙结合微丝蛋白为保护癌细胞如何在分子水平上对抗一种名为顺铂的化疗药物的这一过程
这个发现是非常重要的,因为这会帮助临床医生根据钙结合微丝蛋白的量去确定最有效地治疗方案但该项工作需要非常精确的确定钙结合微丝蛋白的量,因为量的确定可以明确针对癌症所持有的化疗抗性等特点制定具体的方案
“卵巢囊肿的最佳治疗我们相信这个发现是一个有前景的新治疗方法,这种方法在治疗妇女的卵巢癌时为其减少药物抗性有非常大的希望” dar-bin shieh博士说
“我们的发现能够更好地帮助临床医生诊断卵巢癌患者,”ben tsang博士说,“关键是要了解钙结合微丝蛋白的作用,我们发现该蛋白水平的增长与卵巢癌的形成有关,这很可能是卵巢癌对化学疗法产生抗性的原因
cell fate regulation by gelsolin in human gynecologic cancers
据2009年估计,大约有1/72的加拿大妇女在她们的生命期限中卵巢癌会恶化,约有1/93的加拿大妇女会因此而丧命(生物谷bioon.com)
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